Required to investigate the connection between a gene and a disease. Research the science literature, explore biomedical databases and apply bioinformatics tools and approaches to deliver a clearly explained, scientifically accurate and informative report on the assigned topic. Topic: Cerebral amyloid angiopathy (disease) Cystatin C (protein) CST3 (gene) Information covering: Overview a. Concise introduction to the topic and its relevance to medicine & society b. Summary of the relevant gene and mutations, the relevant protein function and dysfunction, and connection to disease
2. The Gene a. Explanation of normal gene function and expression b. Description of gene structure (e.g. introns/exons, regulatory elements) c. Examination and analysis of gene dysfunction (e.g. common/rare gene variation/mutation) d. Details of gene locus and conservation/usefulness in animal models
3. The Protein a. Explanation of normal protein function b. Description of protein properties (e.g. size, domains, structure) c. Details of protein family/class and relevance to animal models d. Analysis of protein dysfunction (e.g. impact of mutations on function)
4. The Disease a. Description of disease manifestation, symptoms, diagnosis, prevalence (e.g. patients and populations affected) b. Explanation and analysis of the molecular basis of the disease (e.g. connection to gene & protein dysfunction) c. Explanation of the cellular & physiological basis of the disease (e.g. connection to cells, tissues, organs, body systems affected) d. Discussion of current and future potential for treatment References from 2011-2017 and use 10 references. Biology Assignment: I need help writing a research paper.
