Required to further investigate the connection between a gene, protein and disease, Research the literature and apply bioinformatics tools to deliver a clearly explained, scientifically accurate and information. Should focus closely on the link between protein structure and function in disease. Overview a. Overview of the topic (connection between gene, protein, and disease), and the relevance to patients, medicine and society
2. The Gene-CST3 a. Explanation of normal gene properties (e.g. function, localisation, structure, expression and regulation) and an examination and analysis of gene dysfunction (e.g. common and rare mutations)
3.The Protein-Cystatin C a. Explanation of normal protein function and role in human biology b. Description of the primary structural properties of the protein (e.g. size, molecular weight, domain structure, post-translational modifications) c. Description of the secondary structural properties of the protein (e.g. local sub-structures, motifs and folding) d. Description of the tertiary and quaternary structural properties of the protein (e.g. three- dimensional structure, association of sub-units) e. Analysis of protein dysfunction (e.g. effect(s) of the mutation(s) on protein structure and function) f. Details of protein family/class and relevance to biomedical research
4. The Disease-Cerebral amyloid angiopathy a. Description of disease manifestation, symptoms, diagnosis, prevalence and burden (e.g. patients and populations affected) b. Explanation and analysis of the molecular basis of the disease (e.g. connection between gene mutation, protein dysfunction and disease symptoms/characteristics) c. Description of the cellular and physiological basis of the disease (e.g. connection between cells, tissues, organs, and body systems affected in disease) d. Evidence-based discussion of current and future potential for treatment Information that is concise, interesting and relevant to the topic.Text in paragraphs with bullet points to list key information. Biology Assignment: I need help writing a research paper.
